This outcome suggests that increased anxiety during adolescence is independent of the magnitude of the CORT response to stress in infancy, but that saline injection may activate other systems, as has been shown with restraint stress-induced CRH and AVP mRNA levels in the paraventricular nucleus of the hypothalamus (Dent et al., 2000a,b) and of CRH in the septum (Vazquez et al., 2006) during the SHRP. Here, CRH is linked to Anxiety.