At the same time, reduced TrkB expression is associated with increased apoptosis in depressed and suicide subjects (Dwivedi et al., 2009), and TrkB.FL deficiency in neuronal progenitors in adulthood impairs integration of newborn neurons into hippocampal neural circuits and consequently induces anxiety-like behavior in mice (Bergami et al., 2008). Here, NTRK2 is linked to Anxiety.