The link could be direct with core function in these networks, as the ATX2 (ATAXIN-2) protein, which is implicated in the expression of spinocerebellar ataxia type 2 (or an increased risk of amyotrophic lateral sclerosis and Parkinsonism), is involved in the activation of the rate-limiting circadian clock component PERIOD in Drosophila (Lim and Allada, 2013) and their daily locomotor behavior (Zhang et al., 2013). This evidence concerns the gene ATXN2 and spinocerebellar ataxia type 2.