ELK1 and Huntington disease: In basal condition, Elk-1 is ubiquitously expressed in the brain, but in HD mice models R6/1 and R6/2, and in immortalized HD mouse (Q111/Q111) cells, Elk-1 has a higher protein expression level and phosphorylation, and is found in the nucleus of the MSNs of 30 weeks old R6/1 mice and 12 weeks old R6/2 mice.