The observation that RGNEF is able to immunoprecipitate NEFL mRNA from ALS spinal cord homogenates and not from controls suggests a preferential interaction in ALS that would be predicted to suppress NEFL mRNA levels, consistent with the loss of NEFL mRNA detected by in situ hybridization in ALS motor neurons (Wong et al., 2000). This evidence concerns the gene NEFL and amyotrophic lateral sclerosis.