EPM2A and Lafora disease: Lafora disease patients present a distinctive EEG pattern characterized by slowing of background activity with recurrent epileptiform discharges: 3–6 Hz spikes/polyspikes, with or without slow waves (Van Heycop Ten Ham, 1974), similar to that observed in spontaneous seizures developed by Epm2a−/− and Epm2b−/− mice (Ganesh et al., 2002; Garcia-Cabrero et al., 2012).