More recently, variants in COQ2 has been proposed as a cause of familial MSA and a risk factor for sporadic clinically diagnosed MSA in the Japanese population (Multiple-System Atrophy Research Collaboration, 2013), which has failed to be replicated so far (Jeon et al., 2014; Schottlaender et al., 2014; Sharma et al., 2014). This evidence concerns the gene COQ2 and multiple system atrophy.