It has to be mentioned that the results of our copy-number analysis demonstrated a gain of chromosome 1q22; however, homozygosity of the V78M variant observed in two of the CRCs could nevertheless indicate that SEMA4A acts as a tumour suppressor rather than a proto-oncogene in the context of familial colorectal tumorigenesis. The gene discussed is SEMA4A; the disease is neoplasm.