SEMA4A and cancer: Unfortunately, due to low-quality DNA obtained from formalin-fixed, paraffin-embedded (FFPE) tumour specimens as well as lack of appropriate heterozygous microsatellite loci within or adjacent to the SEMA4A gene, we were unable to prove the type of LOH in tumours of Family K. Whether public data indicating that the SEMA4A gene is predominantly amplified in diverse cancers can also be interpreted this way, should be handled with extreme caution as context specific functions have to be taken into account.