HOXA10 and acute myeloid leukemia: This myeloproliferative disorder evolving to AML (acute myeloid leukaemia) over time in HOXA10-overexpressing mice, demonstrates that HOXA10 acts as an important regulator of haematopoiesis, governing both proliferation and differentiation of hematopoietic progenitor and stem cells, where distinct fate outcomes depend on the HOXA10 concentration [4–6].