ICAM1 and pulmonary emphysema: Similarly, with regard to the LP15A emphysema outcome variable, meta-analysis with the TESRA cohort validated the association of RAGE (p = 2.5 × 10−10), ICAM1 (p = 6.0 × 10−11), and AXL (p = 3.8 × 10−3) with radiologic emphysema independent of covariates (Table 3).