To explore the pathological properties of TMEM207 in gastrointestinal tumors, we originally generated several C57BL/6-Tg (ITF-TMEM207) mouse lines, designated C57BL/6-Tg (ITF-TMEM207), in which murine TMEM207 is ectopically expressed under the proximal promoter (truncated by ~200 bp) of the murine intestinal trefoil factor (ITF) gene (also known as Tff3). Here, TMEM207 is linked to digestive system neoplasm.