MECP2 and autism spectrum disorder: Overexpression of MeCP2 via transgenic mouse studies or in patients with MeCP2 Duplication Syndrome link core behavioral aspects of Autism Spectrum Disorder (ASD) directly to MeCP2 cellular effects and expand the clinical relevance of understanding MeCP2 function (Coutinho et al., 2007; Neul, 2012; Ramocki et al., 2009).