CDK5 and early-onset autosomal dominant Alzheimer disease: MiR-103a-3p and miR-107 have been recently shown to target human CDK5R1[30], coding for the regulatory subunit 1 of cyclin-dependent kinase 5, a protein found to be hyperactivated in different neurodegenerative diseases, including Parkinson’s and Alzheimer's diseases [31, 32].