The diffuse pattern of p-tau immunostaining was similar to what has been described in patients with preclinical AD or in the pretangle stage [70, 74], suggesting that in HIVE some of the initial triggering events are present [55] which is in agreement with the previous study by Anthony et al. [54] and suggests HIV patients, whether on cART or not, may develop tau pathology beyond the extent seen at the age relatively young ages of the patients of these studies and that tau pathology may reach the threshold for clinical manifestation as the aging process continues [54]. Here, MAPT is linked to Alzheimer disease.