There are two systematic reviews of studies that compare V2 antagonists with placebo (a total of 15 studies were included in both reviews, out of which only the SALT study was a control one) and five comparative studies published later, demonstrating a globally positive effect in favor of the V2 antagonist regarding the elevation of serum sodium levels with no impact on survival and with not a single case of osmotic pontine demyelination. This evidence concerns the gene TRGV9 and Peripheral demyelination.