Moreover, high TCTN1 mRNA expression (n =132) could significantly predict a worse overall survival for GBM patients in comparison with low TCTN1 expression (n =49; Log-rank P =0.013; HR =1.54, 95% CI 1.09-2.17; Figure 4B), which could also serve as an independent prognostic factor in a multivariate Cox regression model (HR =1.58, 95% CI =1.09-2.29, P =0.017; Table 2). This evidence concerns the gene TCTN1 and glioblastoma.