For common genetic alterations of GBM, TCTN1 was expressed in correlation with 10 of them, i.e. mutations of TP53, IDH1 and ATRX, amplifications of EGFR, PDGFRA and MYCN, deletions of CDKN2A, CDKN2B, PTEN and PARK2. Interestingly, for several of them (TP53 mutation, EGFR amplification, PTEN deletion and PARK2 deletion), the association was restricted in non-proneural or proneural subtype. The gene discussed is PTEN; the disease is glioblastoma.