In these studies, several features of human OA were induced, such as airway hyperresponsiveness (AHR), neutrophilic inflammation, increased levels of total serum immunoglobulin E (IgE), along with T and B cell proliferation and increased levels of IL-4, IL-10 and IL-13, one day after intranasal instillation of ammonium persulfate (AP) [11], [12]. The gene discussed is IGHE; the disease is airway hyperresponsiveness.