Third, the study revealed relationships among (a) immunization with a non-inflammatory adjuvant (IFA rather than CFA) (Figures 1, 2, 3, 7), (b) humoral immunity against conformationally intact determinants of IgV-MOG (Figures 8, 9, 10, 11, 12), (c) continuous confluent plaques of severe demyelination in spinal cord and brainstem (Figures 4, 5, 6), and (d) a complex atypical neurologic disease that more closely mimics the clinical heterogeneity of MS than the stereotypic ascending paralysis of classical EAE. This evidence concerns the gene MOG and nervous system disorder.