Following recovery, subsequent boosts of rat IgV-MOG in IFA on days 45 and 85 caused a second bout of chronic ‘atypical’ EAE marked by unusual clinical signs: forelimb weakness without hindlimb involvement, ataxia without flaccid paralysis of the tail, dystonia, rigid asymmetric extension of a hindlimb or forelimb (as opposed to flaccid paralysis), and/or vertigo/disequilibrium and torticollis. Here, MOG is linked to Ataxia.