Third, the study revealed relationships among (a) immunization with a non-inflammatory adjuvant (IFA rather than CFA) (Figures 1, 2, 3, 7), (b) humoral immunity against conformationally intact determinants of IgV-MOG (Figures 8, 9, 10, 11, 12), (c) continuous confluent plaques of severe demyelination in spinal cord and brainstem (Figures 4, 5, 6), and (d) a complex atypical neurologic disease that more closely mimics the clinical heterogeneity of MS than the stereotypic ascending paralysis of classical EAE. Here, MOG is linked to myeloid sarcoma.