RASSF1 and adrenal cortex carcinoma: Similarly, a sequence change from GCT to TCT at codon 133 (Fig. 3), resulting in an alanine to serine substitution, was identified in exon 3 of the RASSF1A gene in 5 of 50 (10%) ACC tumors and matched salivary gland tissues, and in 2 of 20 (10%) peripheral blood cells of healthy donors.