Additionally, because PI3K/AKT and MAPK signaling mediates the key effects of angiopoietin/Tie2, including a wide range of downstream targets that regulate tumor-associated processes, such as cell growth, cell cycle progression, survival, migration, epithelial-mesenchymal transition, and angiogenesis, we examined the influence of selective PI3K/AKT and MAPK neutralization on Tie2-mediated HSC activation and migration. The gene discussed is AKT1; the disease is neoplasm.