MYC and neoplasm: Because both oncogenes were required in the same cell for tumor induction, it was reasoned that placing both oncogenes on the same molecule would result in increased efficiency of tumor induction; this expectation was confirmed, as 1 μg of the dual-expression plasmid pMSV-T24-H-ras/MSV-c-myc was found to be oncogenic in newborn NIH Swiss mice [11].