In normal pregnancy, EVT-derived exosomes may promote vascular smooth muscle cell migration favoring the spiral uterine arterial remodeling; however, high concentration of proinflammatory cytokines (e.g., TNF-α) may inhibit the effect of exosomes on vascular smooth muscle cell migration, triggering failure in arterial remodeling and stimulating the emergence of preeclampsia (Figure 2). The gene discussed is TNF; the disease is preeclampsia.