CD4 and Sepsis: In experimental models of sepsis, IL-7 treatment increased the production of CD4 and CD8 cells, restored delayed type hypersensitivity responses, blocked lymphocyte apoptosis, reversed the impaired IFN-γ production leading to macrophage activation, increased expression of cell-adhesion molecules leading to improved T cells recruitment to sites of infection, and increased T-cell receptor diversity leading to more potent immunity against pathogens [120].