HIF1A and colon adenocarcinoma: When the antiangiogenesis drug Endostar combined with radiotherapy was applied on A549 cells, increased radiation sensitivity by transcriptional factors expression reduction of TGF-β1 and HIF-1α was noticed [72], and it was observed in human colon adenocarcinoma cell line WiDr surviving after radiation therapy by acquiring HIF-1 activity and translocation towards tumor blood vessels in a dependent cellular dynamics after irradiation recurrence, what might suggest basis for targeting HIF-1 after radiation therapy [73, 74], especially in hypoxic tumors.