Another well-known type of molecules involved in cancer progression after IR is the members of a disintegrin and metalloproteinase (ADAM) family that are thought to mediate the shedding of epidermal growth factor receptor (EGFR) ligands, an important signaling pathway to cell proliferation and migration, and this event is critical for a more soluble functional EGFR ligands yield. Here, EGFR is linked to cancer.