Since genetic mechanisms may play a role in determining susceptibility to vascular disease, we studied several mutations in patients with varicose veins to look for any association between varicose veins and homocysteine level, protein C, protein S, FV, FVIII, D-dimer, vitamin B12 level, folic acid level, MTHFR, FVR2, B fibrinogen, FV Leiden, and prothrombin mutations besides other possible factors. The gene discussed is PROS1; the disease is Varicose veins.