Several signaling pathways are involved in the progression of atherosclerosis and restenosis and the key players include peroxisome proliferators-activated receptor gamma (PPARγ) [3], platelet-derived growth factors (PDGF) [4], endothelin-1 (ET-1) [5], thrombin, fibroblast growth factor (FGF) [6]. Here, EDN1 is linked to atherosclerosis.