P70S6K is the primary readout used to assess the activity of the mTOR pathway [6, 34]; the lack of change in P70S6K phosphorylation after mixed-meal consumption in men with MetS is similar to the anabolic resistance induced by periods of inactivity [11, 12] and is observed in older adults [9, 14]. The gene discussed is RPS6KB1; the disease is metabolic syndrome.