In our studies, we did not observe a change in the expression of CD107a in NK cells co-cultured with HeLa, SiHa, or C-33A CCC pre-treated or not with the HO-1 inhibitor (SnPP), although we did observe an increase in the production of TNF-α and IFN-γ in CD107a + NK-92 cells co-cultured with cancer cells pre-treated with the HO-1 inhibitor. The gene discussed is TNF; the disease is cancer.