Recent studies demonstrated that another SNP located in ODD of HIF-1α, 1772 C > T (rs11549465), may lead to an amino acid change from proline 582 to serine (P582S) and are reportedly associated with renal [18,19], head and neck [20], prostate [21], lung [22], and pancreatic [23] cancers. This evidence concerns the gene HIF1A and cancer.