AKT1 and chondrosarcoma: We showed overexpression of CCL5 promoting VEGF expression and increasing angiogenesis in vitro and in vivo. One mechanism underlying CCL5 increased VEGF production and angiogenesis by down-regulating miR-200b through PI3K and Akt signaling pathway, rendering CCL5 a novel target for chondrosarcoma angiogenesis and metastasis