We transfected E1A or control expression vectors into a panel of breast cancer cell lines to investigate the effects of E1A on HSPA5 expression and found that E1A suppressed HSPA5 expression and cell migration/invasion in three breast cancer cell lines (MDA-MB-231, HS578T and HBL100 cells) (Fig. 1A). Here, HSPA5 is linked to breast cancer.