As expected, knocking down ESL-1 impairs PCa cells' rolling capacity significantly, where we found a significantly fewer number of shESL-1 PC-3 and shESL-1 DU145 cells can roll and adhere to the coated microtubes under shear stress 1 dyne/cm2 (Figure 5C and Supplementary Figure S5A). Here, GLG1 is linked to posterior cortical atrophy.