Among other tissue-specific genes regulated by POU2F1 are osteopontin [15], iNOS [16] and the caudal homeobox gene Cdx-2, itself a transcriptional activator for a cohort of genes specifically expressed in pancreatic islets and intestinal cells and implicated in the prevention of the development of colorectal tumors [17]. The gene discussed is POU2F1; the disease is colorectal neoplasm.