We earlier showed that not only did loss of wild-type APC increase resistance of HCT116 CRC cells to the effects of 5-FU (Supplementary Fig. S2A), but that overexpression of mutant APC(1-1309) could increase 5-FU resistance in non-tumor HEK293 cells (Supplementary Fig. S3). The gene discussed is APC; the disease is colorectal carcinoma.