Retrospectively, the correlation between clinical parameters (RR, PFS and OS) and EGFR and K-Ras mutational status showed that women with EGFR mutant tumor achieved a marginally lower RR to first-line platinum-based combination (32% vs. 43%; p = 0.579) and a significantly shorter PFS (4.4 vs. 6.4 months; HR 0.597; p = 0.048) compared to those with wild-type disease. The gene discussed is KRAS; the disease is neoplasm.