Other larger data sets did not suggest any relevance of K-Ras mutations in determining the benefit of CT [16], and taking into account the above mentioned conflicting results about the predictive role for anti-EGFR TKIs [17,18], we do not believe that routine K-Ras sequencing should be considered in all patients with lung adenocarcinoma outside clinical and translational trials. The gene discussed is KRAS; the disease is lung adenocarcinoma.