ESR2 and hypopituitarism: The billowing use of alternative medicines and in particular herbal products and TCMs by adults and children [31] is based on the popular belief that these products are “harmless.” Based on the knowledge that there are numerous estrogens with varying degrees of selectivity for ERα and ERβ in many TCMs [14], we hypothesized that the TCM, which was prescribed by a naturopath to a short-statured 4-year-old boy with multiple pituitary hormone deficiencies, would contain components with potent estrogen activity and would be responsible for the child's growth acceleration and bone maturation.