PLX4032 and PLX4720 also sensitised two wild-type BRAF melanoma cell lines, IPC-298 and SK-Mel-30 (DSMZ, Braunschweig, Germany), that express ABCB1, ABCC1, and ABCG2 (Additional file 4: Table S3) to vincristine and mitoxantrone (Additional file 5: Table S4). The gene discussed is ABCC1; the disease is melanoma.