HDL-p remained independently associated with coronary artery disease (CAD) risk after adjusting for triglyceride, ApoB, C-reactive protein (CRP) and other markers of inflammation (adjusted odds ratio (OR) 0.50, 95%CI 0.37–0.66, comparing the highest to the lowest quarters for the HLD-p distribution). The gene discussed is CRP; the disease is coronary artery disorder.