As PI3K/AKT pathway is known to induce cell cycle progression.13 Cell cycle is regulated by highly multifaceted proteins that include cyclins, CDKs as well as CDKis.38 This prompted us to study the expression profile of cyclins in the present study and we could observe that HBA induced cell cycle arrest by downregulating the expression of cyclins D, E and A in HL-60, THP-1 and MCF-7 cells suggests that these proteins have been involved in cell cycle progression in leukemia and breast cancer cell lines employed. The gene discussed is AKT1; the disease is breast carcinoma.