AKT1 and cancer: AKT can modulate bad activity by phosphorylating at Ser112,39 and phosphorylated Bad then dissociates from bcl2 to form a complex with the 14-3-3 adaptor protein leading to cell survival.40 We observed decrease in the expression of bcl2 protein in all the three cancer cell lines that was associated with elevated levels of bax protein in a dose-dependent manner.