CIB1 and cancer: As we have found inhibition in the expression of cyclins by treatment with HBA in all the three cancer cell lines, we wanted to study whether the treatment of HBA will affect the expression of any of the CDKis, and we observed that HBA treatment to the cancer cells of different histogenic origin caused drastic upregulation in the expression of p21 and p27 cip/kip proteins in a concentration-dependent manner (Figures 4a–c).