NFKB1 and neoplasm: In addition to genetic alterations,4 a chronic inflammatory environment and the interaction of epithelial tumour cells with the surrounding tumour stroma are involved in PDAC development and apoptosis resistance.5 These alterations lead to a deregulated activity of several potentially oncogenic and inflammation related transcription factors, including NF-κB, NFAT and Nrf2.6,7