A pivotal role in carcinogenesis and chemoresistance of a great number of tumours, including PDAC, has been shown for NF-κB.4,6,8, 9, 10 This transcription factor is composed as a hetero- or homodimer of members of the so-called Rel family.4,6,11 Proteins of this family harbour a Rel homology domain, which mediates dimerization as well as the interaction with inhibitory components of the pathway. Here, REL is linked to neoplasm.