It similarly maintains a strong level ofpSTAT3Ser727 immunolabeling in absence of any immunoreactive pSTAT3Tyr705 inCLL-BC even after prolonged periods (Figures 5c and d, right panels, andSupplementary Figure 3), while the expression of total STAT3 remainsunchanged (data not shown). The gene discussed is STAT3; the disease is breast cancer.