VEGFA and B-cell chronic lymphocytic leukemia: Several reports have shown that pSTAT3Ser727 activation in the absence of canonicalpSTAT3Tyr705 mediates cell survival messages, as illustrated by the action ofneutrotrophins on both neuronal stem/progenitor and mature cells, or VEGF activity on CLL-BCcultured alone.23, 24, 25, 26 DNA damage inducers similarlyactivate pSTAT3Ser727 but not pSTAT3Tyr705 expression in cancer cell models,thereby enhancing DNA repair.27 In these analyses,pSTAT3Ser727 activity involved nuclear transcriptional regulation of cellsurvival/DNA repair genes.