NGF and ischemia: It howeverprotected murine cardiomyocytes from ischemia and decreased the production of ROS andcytochrome-c release.28 Also, MtpSTAT3Ser727 is involved in nerve growth factor-induced neurite outgrowth and theproduction of ROS.29 Remarkably, MtpSTAT3Ser727 is overexpressed by Ras-transformed mouse embryo fibroblasts and supportsRas-dependent malignant transformation.11 It furtherinfluences the tumorigenic potential of murine 4T1 breast cancer cells that correlates with theregulation of ROS concentrations.30