MYC and pancreatic neuroendocrine tumor: Although MYC is not frequently deregulated in PanNETs, several observations suggested that MYC activation appeared to be an early event in human islet cell tumor progression.32,33 Studies in transgenic mouse models with conditional Myc expression showed that Myc gene expression is not only required for the initiation of PanNETs but also important in maintaining the tumorigenicity of PanNETs.7,34 In this study, we extended these observations and confirmed that downregulation of MYC protein in PanNET cells upon BETi treatment inhibited cell proliferation and had antitumor effects in vivo.