BRD4 and lymphoma: It has been reported that (+)-JQ1 reduces MYC in lymphoma and leukemia cell lines through BRD4 protein bromodomain inhibition, and deregulated expression of MYC exerts significant roles on cell cycle progression.17Figure 2a showed that at 24 h upon CPI203 treatment, MYC mRNA was downregulated by about two- or three-fold in BON-1 or QGP-1 cells respectively, and MYC protein was reduced in a dose-dependent manner with a slightly stronger reduction of MYC protein in BON-1 cells than in QGP-1 cells.