NGB and cancer: High oxidative stress represents a hallmark of many cancers31 and could drive cancer cells to apoptosis.32 However, cancer cells undergo metabolic and transcriptional adaptations against stress agents, allowing cancer cells to survive even when the redox status is imbalanced.21 NGB could act as a compensatory protein in E2-related cancers as reported in neurons.27 The results reported here confirm that H2O2 renders cells more prone to the pro-apoptotic cascade activation in both HepG2 and MCF-7 cells.