BCL2L11 and cancer: Otherwise, it was recently shown that BIM and PUMA could cooperate to induce cell death in several cancer cell lines in response to EGFR pathways inhibition.37 However, the absence of induction of PUMA by miR-491-5p as well as the almost complete protection from miR-491-5p-induced apoptosis by a siRNA targeting BIM suggested that PUMA does not play a major role in miRNA-mediated cell death, at least in IGROV1-R10 cells.