BECN1 and breast carcinoma: Although Beclin1 was most of the time perceived as key player in autophagy execution and its knock down blocks autophagic cell death [37], a recent study by Wong and collaborators showed that small molecule compound, referred as C1, that triggers intracellular ROS production, induced simultaneous induction of Beclin1-independent autophagy and apoptosis in various cancer cell type including MDA-MB-231 breast cancer cells [21].