CFTR and cystic fibrosis: Insulin resistance can be hypothesized as being related to the basic genetic defect, thus to CFTR malfunctioning, as well as to mechanisms depending on inflammation [8,9] and/or to other recently described mechanisms as reduced autophagy, and endoplasmic reticulum stress [15,16,17,18], CF is a well-recognized condition of chronic inflammation both at the cellular and systemic level.