There were no differences in the changes in any of the insulin sensitivity or secretion measures, or in the disposition index, between the treatment and placebo groups, even after taking into account the variables that were different between groups at baseline (fasting glucose, waist circumference, season of recruitment, prediabetes status, systolic and diastolic blood pressure, hs-CRP, IL-6, current smoking and dietary vitamin D intake) (Table 2). This evidence concerns the gene INS and prediabetes syndrome.