In two spontaneous metastasis models, the B16F10.9 melanoma (B16) and the Lewis lung carcinoma (D122) in the NCR1 knockout mouse, NKp46/NCR1 is directly involved in the killing of B16 and D122 cells in vitro and plays an important role in controlling B16 and D122 metastasis in vivo [36]. This evidence concerns the gene NCR1 and Carcinoma, Lewis Lung.