MECP2 and metabolic syndrome: We note that other laboratories reported indications of metabolic syndrome, similar to those in our study of Mecp2 KO mice: male Mecp2-null mice, from crossings of C57BL6 males with heterozygous female Mecp2TM1.Bird/+ mice on a 129S6 background, were overweight and obese, exhibited poor responses in GTT and ITT[33], and had increased serum cholesterol and triglycerides[33], [47].