MECP2 and Other metabolic disease: The Mecp2 KO mice in the present study did not suffer untoward effects with triheptanoin diet; further study is warranted to investigate this issue, but the mitigation of RTT-like symptoms with triheptanoin diet was impressive in the present studies in mice, and has been well-tolerated in patients with other metabolic diseases[24], [28]–[31].