Hexanucleotide repeat expansions in an intron of C9ORF72 were recently shown to be causative for ALS [19], [20]; the Coriell repository ALS samples have previously been analyzed for expansions in the intron of C9ORF72 and 11.8% of them carry an expanded allele [46]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.