While no single gene emerged as significantly enriched in our analysis, we did find several genes that trended towards more novel and rare variants in ALS patient samples versus controls (Figure 1B and Table S1), including SRCAP (trios, 10 novel or rare variants in patients versus 2 in controls) and AIM1L (trios, 5 novel or rare variants in patients versus 1 in controls). Here, SRCAP is linked to amyotrophic lateral sclerosis.