TARDBP and amyotrophic lateral sclerosis: For example, we previously used a candidate approach to identify novel ALS disease genes by looking for genes that behaved similarly to the well-known ALS disease genes, TARDBP and FUS. Both TDP-43 (the protein product of the TARDBP gene) and FUS contain RNA Recognition Motifs (RRMs) and prion-like domains, and aggregate and are toxic in yeast, mimicking their behavior in disease [5], [6].