Several recent studies have linked ALS and stress granules; stress granule proteins have been found colocalized with protein inclusions in patient samples and in models of the disease and several ALS disease proteins are also stress granule proteins, including TDP-43, FUS, TAF15, EWSR1, ANG, PFN1 and ATXN2 [126], [131]–[134]. Here, PFN1 is linked to amyotrophic lateral sclerosis.